Review Article| Volume 26, ISSUE 1, P175-186, January 2023

Hystricomorph Rodent Analgesia


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        • Ellen Y.
        • Flecknell P.
        • Leach M.
        Evaluation of using behavioural changes to assess postoperative pain in the guinea pig (Cavia Porcellus).
        PLoS One. 2016; 11: 1-20
        • Moeremans I.
        • Devreese M.
        • De Baere S.
        • et al.
        Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus).
        Vet Anal Anesth. 2019; 46: 548-555
        • Foley P.L.
        • Kendall L.V.
        • Turner P.V.
        Clinical Management of Pain in Rodents.
        J Am Assoc Lab Anim Sci. 2019; 69: 468-489
        • Kest B.
        • Wilson S.G.
        • Mogil J.S.
        Sex differences in supraspinal morphine analgesia are dependent on genotype.
        J Pharmacol Exp Ther. 1999; 289: 1370-1375
        • Mogil J.S.
        • Wilson S.G.
        • Bon K.
        • et al.
        Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception.
        Pain. 1999; 80: 67-82
        • Bays T.B.
        Guinea pig behavior.
        in: Bays T.B. Lightfoot T. Mayer J. Exotic pet behavior: birds, reptiles, and small animals. Saunders Elsevier, St Louis2006: 207-238
        • Dunbar M.L.
        • David E.M.
        • Aline M.R.
        • et al.
        Validation of a behavioral ethogram for assessing postoperative pain in guinea pigs (Cavia porcellus).
        J Am Assoc Lab Anim Sci. 2016; 55: 29-34
        • Leach M.C.
        • Coulter C.A.
        • Richardson C.A.
        • et al.
        Are we looking in the wrong place? Implications for behavioral-based pain assessment in rabbits (Oryctolagus cuniculi) and beyond?.
        PLoS One. 2011; 6: e13347
        • Leach M.C.
        • Allweiler S.
        • Richardson C.
        • et al.
        Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory-housed rabbits.
        Res Vet Sci. 2009; 87: 336-347
        • Oliver V.L.
        • Athavale S.
        • Simon K.E.
        • et al.
        Evaluation of pain assessment techniques and analgesia efficacy in a female guinea pig (Cavia porcellus) model of surgical pain.
        J Am Assoc Lab Anim Sci. 2017; 56: 425-435
        • Ambros B.
        • Knych H.K.
        • Sadar M.J.
        Pharmacokinetics of hydromorphone hydrochloride after intravenous and intramuscular administration in guinea pigs (Cavia porcellus).
        Am J Vet Res. 2020; 81: 361-366
        • Rockwell K.
        Therapeutic review: buprenorphine.
        J Exot Pet Med. 2019; 30: 12-16
        • Plumb D.C.
        in: Plumb’s veterinary drug handbook. PharmaVet, Stockholm2017: 181-183
        • Sadar M.J.
        • Knych H.K.
        • Drazenovich T.L.
        • et al.
        Pharmacokinetics of buprenorphine after intravenous and oral transmucosal administration in guinea pigs (Cavia porcellus).
        Am J Vet Res. 2018; 79: 260-266
        • Zanetti A.S.
        • Putta S.K.
        • Casebolt D.B.
        • et al.
        Pharmacokinetics and adverse effects of 3 sustained-release buprenorphine dosages in healthy guinea pigs (Cavia porcellus).
        J Am Assoc Lab Anim Sci. 2017; 56: 768-778
        • Fox L.
        • Mans C.
        Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera).
        J Am Assoc Lab Anim Sci. 2018; 57: 286-290
        • Foley P.L.
        Current options for providing sustained analgesia to laboratory animals.
        Lab Anim (NY). 2014; 43: 364-371
        • Pettifer G.
        • Hydromorphone D.D.
        A cost-effective alternative to the use of oxymorphone.
        Can Vet J. 2000; 41: 135-137
        • Evenson E.A.
        • Mans C.
        Analgesic efficacy and safety of hydromorphone in chinchillas (Chinchilla lanigera).
        J Am Assoc Lab Anim Sci. 2018; 57: 282-285
        • Hawkins M.
        • Pascoe P.J.
        Anesthesia, analgesia, and sedation of small mammals.
        in: Quesenberry K.E. Orcutt C.J. Mans C. Ferrets, rabbits, and rodents: clinical medicine and surgery. 4th edition. Elsevier, St. Louis2020: 536-558
        • Lewis K.S.
        • Han N.H.
        Tramadol: a new centrally acting analgesic.
        Am J Health Syst Pharm. 1997; 54: 643-652
        • Mayer J.
        in: Carpenter J.W. Exotic animal formulary. 2nd edition. Elsevier, St. Louis2013: 494
        • Guzman-Silva M.A.
        • Pollastri C.E.
        • Pantaleao J.A.S.
        • et al.
        Tramadol minimizes potential pain during post-oophorectomy in Wistar rats.
        Altern Anim Exp. 2007; 14: 91-92
        • Tsai Y.C.
        • Sung Y.H.
        • Chang P.J.
        • et al.
        Tramadol relieves thermal hyperalgesia in rats with chronic constriction injury of the sciatic nerve.
        Fundam Clin Pharmacol. 2000; 14: 335-340
        • KuKanich B.
        • Wiese A.J.
        in: Grimm K.A. Lamont L.A. TRanquillie W.J. Lumb & jones’ veterinary anesthesia and analgesia. 5th edition. Wiley, Ames2015: 207-226
        • Delgado C.
        • Bentley E.
        • Hetzel S.
        • et al.
        Comparison of carprofen and tramadol for postoperative analgesia in dogs undergoing enucleation.
        J Am Vet Med Assoc. 2015; 245: 1375-1381
        • Garrido M.J.
        • Sayar O.
        • Segura C.
        • et al.
        Pharmacokinetic/pharmacodynamic modeling of the antinociceptive effects of (+)-tramadol in the rat: role of cytochrome P450 2D activity.
        J Pharmacol Exp Ther. 2003; 305: 710-718
        • Beakley B.D.
        • Kaye A.M.
        • Kaye A.D.
        Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review.
        Pain Physician. 2015; 18: 395-400
        • Ogino K.
        • Hatanaka K.
        • Kawamura M.
        • et al.
        Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1.
        Pharmacology. 1997; 55: 44-53
        • Fox A.
        • Gentry C.
        • Patel S.
        • et al.
        Comparative activity of the anticonvulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea pig.
        Pain. 2003; 105: 355-362
        • Corona-Ramos J.
        • De la O-Arciniega M.
        • Déciga-Campos M.
        • et al.
        The antinociceptive effects of tramadol and/or gabapentin on rat neuropathic pain induced by a chronic constriction injury.
        Drug Dev Res. 2016; 77: 217-226
        • Spittler A.P.
        • Helbling J.E.
        • McGrath S.
        • et al.
        Plasma and joint tissue pharmacokinetics of two doses of oral cannabidiol oil in guinea pigs (Cavia porcellus).
        J Vet Pharmacol Ther. 2021; 44: 967-974
        • O'Brien M.
        • McDougall J.J.
        Cannabis and joints: Scientific evidence for the alleviation of osteoarthritis pain by cannabinoids.
        Curr Opin Pharmacol. 2018; 40: 104-109
        • Flecknell P.A.
        Rodent analgesia: Assessment and therapeutics.
        Vet J. 2018; 232: 70-77
        • Grant G.J.
        • Piskoun B.
        • Lin A.
        • et al.
        An in vivo method for the quantitative evaluation of local anesthetics.
        J Pharmacol Toxicol Methods. 2000; 43: 69-72
        • DiGeronimo P.M.
        • da Cunha A.F.
        Local and regional anesthesia in zoological companion animal practice.
        Vet Clin Exot Anim Pract. 2022; 25: 321-336
        • Smith B.J.
        • Wegenast D.J.
        • Hansen R.J.
        • et al.
        Pharmacokinetics and paw withdrawal pressure in female guinea pigs (Cavia porcellus) treated with sustained-release buprenorphine and buprenorphine hydrochloride.
        J Am Assoc Lab Anim Sci. 2016; 55: 789-793
        • Flecknell P.A.
        Guinea pigs.
        in: Meredith A. Redrobe S. BSAVA manual of exotic pets. 4th ed. BSAVA, Gloucester2002: 52-64
        • Flecknell P.A.
        Analgesia and post-operative care.
        in: Flecknell P.A. Laboratory animal anaesthesia. 3rd edition. Academic Press, Elsevier, London2009: 139-179
        • Gleeson M.
        • Hawkins M.G.
        • Howerton C.L.
        • et al.
        Evaluating postoperative parameters in guinea pigs (Cavia porcellus) following routine orchiectomy.
        J Exot Pet Med. 2016; 25: 242-252