Review Article| Volume 26, ISSUE 1, P187-199, January 2023

Pain Recognition in Rabbits


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        • Pet Population report PFMA
        Pet Population report 2022.
        (Accessed August 15, 2022.)
      1. Home Office. Statistics of Scientific Procedures on living animals, Great Britain 2018. UK government document publised by the Home Office. Available at: Accessed August 15, 2022.

      2. American Veterinary Medical Association (AVMA) U.S. Pet ownership & demographics sourcebook. 2007. Available at: Accessed August 15, 2022.

      3. American Veterinary Medical Association (AVMA) U.S. Pet ownership & demographics sourcebook. 2018. Available at: Accessed August 15, 2022.

        • Lascelles B.D.
        • Capner C.A.
        • Waterman-Pearson
        Current British attitudes to perioperative analgesia for cats and small mammals.
        Vet Rec. 1999; 145: 601-604
        • Capner C.A.
        • Lascelles B.D.
        • Waterman-Pearson A.E.
        Current British attitudes to perioperative analgesia for dogs.
        Vet Rec. 1999; 145: 95-99
        • Coulter C.A.
        • Flecknell P.A.
        • Richardson C.A.
        Reported analgesic administration to rabbits, pigs, sheep, dogs and non-human primates undergoing experimental surgical procedures.
        Lab Anim. 2009; 43: 232-238
        • Coulter C.A.
        • Flecknell P.A.
        • Leach M.C.
        • Richardson C.A.
        Reported analgesic administration to rabbits undergoing experimental surgical procedures.
        BMC Vet Res. 2011; 7: 12
        • Benato L.
        • Rooney N.J.
        • Murrell J.C.
        Pain and analgesia in pet rabbits within the veterinary environment: a review.
        Vet Anaesth Analgesia. 2019; 46: 151-162
        • Jirkof P.
        Side effects of pain and analgesia in animal experimentation.
        Lab Animal. 2017; 46: 123-128
        • Kohn D.F.
        • Martin T.E.
        • Foley P.L.
        • Morris T.H.
        • Swindle M.M.
        • Vogler G.A.
        • Wixson S.A.
        Guidelines for the assessment and management of pain in rodents and rabbits.
        J America Assoc Lab Anim Sci. 2007; 46: 97-108
        • Spitzagel M.B.
        • Jacobson D.M.
        • Cox M.D.
        • et al.
        Predicting caregiver burden in general veterinary clients: Contribution of companion animal clinical signs and problem behaviors.
        Vet J. 2018; 236: 23-30
      4. Barter, L. Rabbit Analgesia. Vet Clin North Am Exot Anim Pract, 14, 2011, 93–104.

        • National Research Council
        Recognition and alleviation of pain in laboratory animals.
        The National Academies Press, Washington, DC2009: 47-69
        • Varga M.
        Analgesia and pain management in rabbits.
        Vet Nurs J. 2016; 31: 149-153
        • Leach M.C.
        • Allweiler S.
        • Richardson C.A.
        • et al.
        Behavioural effect of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits.
        Res Vet Sci. 2009; 87: 336-347
        • Pinho R.H.
        • Leach M.C.
        • Minto B.W.
        • et al.
        Postoperative pain behaviours in rabbits following orthopedic surgery and effect of observer presence.
        PLoS One. 2020; 15: e:0240605
        • Benato L.
        • Murrell J.
        • Knowles T.J.
        • Rooney N.J.
        Development of the Bristol rabbit pain scale (BRPS): a multidimensional composite pain scale specific to rabbits (Oryctolagus cuniculus).
        PLoS One. 2021; 16: e:0252417
      5. Oglesbee BL, Lord B. Gastrointestinal Diseases of Rabbits. Ferrets, Rabbits, and Rodents 2020:174–87. doi: 10.1016/B978-0-323-48435-0.00014-9.

        • Weaver L.A.
        • Blaze C.A.
        • Linda D.E.
        • Andrutis K.A.
        • Karas A.Z.
        A model for clinical evaluation of perioperative analgesia in rabbits (Oryctolagus cuniculus).
        J Am Assoc Lab Anim Sci. 2010; 49: 845-851
        • Roughan J.V.
        • Flecknell P.A.
        Evaluation of a short duration behaviour-based post-operative pain scoring system in rats.
        Eur J Pain. 2003; 7: 397-406
        • Ellen Y.
        • Flecknell P.A.
        • Leach M.C.
        Evaluation of using behavioural changes to assess post-operative pain in the guinea pig (Cavia porcellus).
        PLoS One. 2016; 11: e0161941
        • Vaisanen M.A.M.
        • Tuomikoski S.K.
        • Vainio O.M.
        Behavioural alterations and severity of pain in cats recovering at home following elective ovariohysterectomy or castration.
        J Am Vet Med Assoc. 2007; 231: 236-242
        • Holton L.
        • Reid J.
        • Scott E.M.
        • et al.
        Development of a behaviour based scale to measure acute pain in dogs.
        Vet Rec. 2001; 148: 525-531
        • Farnworth M.J.
        • Walker J.K.
        • Schweizer K.A.
        • Chuang C.L.
        • Guild S.J.
        • Barrett C.J.
        • Leach M.C.
        • Waran N.K.
        . Potential behavioural indicators of post-operative pain in male laboratory rabbits following abdominal surgery.
        Anim Welfare. 2011; 20: 225-237
        • Turner P.V.
        • Chen C.H.
        • Taylor M.W.
        Pharmacokinetics of meloxicam in rabbits after single and repeat oral dosing.
        Comp Med. 2006; 56: 63-67
        • Miller A.L.
        • Clarkson J.M.
        • Quigley C.
        • Neville V.
        • Krall C.
        • Geijer-Simpson A.
        • Flecknell P.A.
        • Leach M.C.
        Evaluating pain and analgesia effectiveness following routine castration in rabbits using behavior and facial expressions.
        Frontieres Vet Sci. 2022; 9: 782486
        • Leach M.C.
        • Coulter C.A.
        • Richardson C.A.
        • Flecknell P.A.
        Are we looking in the wrong place? Implications for behavioural based pain assessment in rabbits (Oryctolagus Cuniculi) and beyond.
        PLoS One. 2011; 6: e13347
        • Peters J.W.B.
        • Koot H.M.
        • Grunau R.E.
        • de Boer J.
        • Druenen H.J.
        • et al.
        Neonatal facial coding system for assessing post operative pain in infants: Item reduction is valid and feasible.
        The Clin J Pain. 2003; 19: 353-363
        • Prkachin K.M.
        The consistency of facial expressions of pain: a comparison across modalities.
        Pain. 1992; 51: 297-306
        • Langford D.J.
        • Bailey A.L.
        • Chanda M.L.
        • et al.
        Coding facial expressions of pain in the laboratory mouse.
        Nat Methods. 2010; 7: 447-449
        • Keating S.
        • Thomas A.A.
        • Flecknell P.A.
        • Leach M.C.
        Evaluation of EMLA cream for preventing pain during tattooing in rabbits: Changes in physiological, behavioural and facial expression responses.
        PLoS One. 2012; 7: e44437
        • Banchi P.
        • Quaranta G.
        • Ricci A.
        • von Degerfeld M.M.
        Reliability and construct validity of a composite pain scale for rabbits (CANCRS) in a clinical environment.
        PLoS One. 2020; 15: e0221377
        • Miller A.L.
        • Leach M.C.
        The mouse grimace scale: a clinically useful tool?.
        PLoS One. 2015; 10: e0136000
        • Leung V.
        • Zhang E.
        • Pang D.S.J.
        Real-time application of the Rat Grimace Scale as a welfare refinement in laboratory rats.
        Scientific Rep. 2016; 6: 31667
        • Banchi P.
        • Quaranta G.
        • Ricci A.
        • von Degerfeld M.M.
        A composite pain scale to recognize abdominal pain and its variation over time in response to analgesia in rabbits.
        Vet Anaesth Analgesia. 2022; 49: 323-328
        • Calvo G.
        • Holden E.
        • Reid J.
        • Scott E.M.
        • Firth A.
        • Bell A.
        • Robertson S.
        • Nolan A.M.
        Development of a behaviour based measurement tool with defined intervention level for assessing acute pain in cats.
        J Small Anim Pract. 2014; 55: 622-629
        • Lawson A.L.
        • Opie R.R.
        • Stevens K.B.
        • Knowles E.J.
        • Mair T.S.
        Application of an equine composite pain scale and its association with plasma adrenocorticotrophic hormone concentrations and serum cortisol concentrations in horses with colic.
        Equine Vet Educ. 2020; 32: 20-27
        • Roughan J.V.
        • Flecknell P.A.
        • Orr H.
        Behavioural assessment of post-operative pain and analgesic effects of carprofen in the domestic rabbit.
        Proc 8th World congress Vet Anaesth. 2004; 31: 1-71
        • Goldschlager G.H.
        • Gillespie V.L.
        • Palme R.
        • Baxter M.G.
        Effects of multimodal analgesia with low dose buprenorphine and meloxicam on fecal glucocorticoid metabolites after surgery in New Zealand White Rabbits (Oryctolagus cuniculus).
        J Am Assoc Lab Anim Sci. 2013; 52: 571-576
        • Flecknell P.A.
        • Waterman-Pearson A.
        Pain management in animals.
        Harcourt Publishers Ltd, London, UK2000: 53-79