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Treatment of Pain in Rabbits

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      REFERENCES

        • Association A.V.M.
        AVMA pet ownership and demographics sourcebook.
        Veterinary Economics Division, 2018
        • Coulter C.A.
        • Flecknell P.A.
        • Leach M.C.
        • et al.
        Reported analgesic administration to rabbits undergoing experimental surgical procedures.
        BMC Vet Res. 2011; 7: 12
        • Nunamaker E.A.
        • Stolarik D.F.
        • Ma J.
        • et al.
        Clinical efficacy of sustained-release buprenorphine with meloxicam for postoperative analgesia in beagle dogs undergoing ovariohysterectomy.
        J Am Assoc Lab Anim Sci. 2014; 53: 494-501
        • Goldschlager G.B.
        • Gillespie V.L.
        • Palme R.
        • et al.
        Effects of multimodal analgesia with LowDose buprenorphine and meloxicam on fecal glucocorticoid metabolites after surgery in New Zealand white rabbits (Oryctolagus cuniculus).
        J Am Assoc Lab Anim Sci. 2013; 52: 571-576
        • Woolf C.J.
        • Chong M.-S.
        Preemptive analgesia—treating postoperative pain by preventing the establishment of central sensitization.
        Anesth Analg. 1993; 77: 362-379
        • Shafford H.L.
        • Schadt J.C.
        Effect of buprenorphine on the cardiovascular and respiratory response to visceral pain in conscious rabbits.
        Vet Anaesth Analg. 2008; 35: 333-340
        • Fleischer S.
        • Sharkey M.
        • Mealey K.
        • et al.
        Pharmacogenetic and Metabolic Differences Between Dog Breeds: Their Impact on Canine Medicine and the Use of the Dog as a Preclinical Animal Model.
        AAPS J. 2008; 10: 110-119
        • KuKanich B.
        • Wiese A.J.
        Opioids.
        Veterinary Anesthesia and Analgesia, 2015: 207-226
        • Hayashida M.
        • Fukunaga A.
        • Fukuda K-i
        • et al.
        A rabbit model for evaluation of surgical anesthesia and analgesia: characterization and validation with isoflurane anesthesia and fentanyl analgesia.
        J Anesth. 2004; 18: 282-291
        • Barter L.S.
        • Hawkins M.G.
        • Pypendop B.H.
        Effects of fentanyl on isoflurane minimum alveolar concentration in New Zealand White rabbits (Oryctolagus cuniculus).
        Am J Vet Res. 2015; 76: 111-115
        • Tearney C.C.
        • Barter L.S.
        • Pypendop B.H.
        Cardiovascular effects of equipotent doses of isoflurane alone and isoflurane plus fentanyl in New Zealand White rabbits (Oryctolagus cuniculus).
        Am J Vet Res. 2015; 76: 591-598
        • Foley P.L.
        • Henderson A.L.
        • Bissonette E.A.
        • et al.
        Evaluation of fentanyl transdermal patches in rabbits: blood concentrations and physiologic response.
        Comp Med. 2001; 51: 239-244
        • Mirschberger V.
        • von Deimling C.
        • Heider A.
        • et al.
        Fentanyl Plasma Concentrations after Application of a Transdermal Patch in Three Different Locations to Refine Postoperative Pain Management in Rabbits.
        Animals. 2020; 10: 1778
        • Weaver L.A.
        • Blaze C.A.
        • Linder D.E.
        • et al.
        A Model for Clinical Evaluation of Perioperative Analgesia in Rabbits (Oryctolagus cuniculus).
        J Am Assoc Lab Anim Sci : JAALAS. 2010; 49: 845-851
        • Weinstock M.
        • Erez E.
        • Roll D.
        Antagonism of the cardiovascular and respiratory depressant effects of morphine in the conscious rabbit by physostigmine.
        J Pharmacol Exp Ther. 1981; 218: 504-508
        • Hayashida M.
        • Fukunaga A.
        • Hanaoka K.
        Detection of acute tolerance to the analgesic and nonanalgesic effects of remifentanil infusion in a rabbit model.
        Anesth Analg. 2003; 97: 1347-1352
        • Yu E.H.
        • Tran D.H.
        • Lam S.W.
        • et al.
        Remifentanil tolerance and hyperalgesia: short-term gain, long-term pain?.
        Anaesthesia. 2016; 71: 1347-1362
        • Chang S.-F.
        • Moore L.
        • Chien Y.W.
        Pharmacokinetics and bioavailability of hydromorphone: effect of various routes of administration.
        Pharm Res. 1988; 5: 718-721
        • Roerig S.
        • Fujimoto J.M.
        • Wang R.I.
        Isolation of hydromorphone and dihydromorphine glucuronides from urine of the rabbit after hydromorphone administration.
        Proc Soc Exp Biol Med. 1973; 143: 230-233
        • Cone E.J.
        • Darwin W.D.
        • Buchwald W.F.
        • et al.
        Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dog.
        Drug Metab Dispos. 1983; 11: 446-450
        • Guedes A.
        • Papich M.
        • Rude E.
        • et al.
        Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs.
        J Vet Pharmacol Ther. 2008; 31: 334-343
        • Schnellbacher R.W.
        • Divers S.J.
        • Comolli J.R.
        • et al.
        Effects of intravenous administration of lidocaine and buprenorphine on gastrointestinal tract motility and signs of pain in New Zealand White rabbits after ovariohysterectomy.
        Am J Vet Res. 2017; 78: 1359-1371
        • DiVincenti L.
        • Meirelles L.A.D.
        • Westcott R.A.
        Safety and clinical effectiveness of a compounded sustained-release formulation of buprenorphine for postoperative analgesia in New Zealand White rabbits.
        J Am Vet Med Assoc. 2016; 248: 795-801
        • Flecknell P.
        • Liles J.
        Assessment of the analgesic action of opioid agonist-antagonists in the rabbit.
        J Assoc Vet Anaesthetists Great Britain Ireland. 1990; 17: 24-29
        • Robertson S.
        • Taylor P.
        • Lascelles B.
        • et al.
        Changes in thermal threshold response in eight cats after administration of buprenorphine, butorphanol and morphine.
        Vet Rec. 2003; 153: 462-465
        • Murphy K.L.
        • Roughan J.V.
        • Baxter M.G.
        • et al.
        Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine.
        Vet Anaesth Analg. 2010; 37: 222-229
        • DiVincenti Jr., L.
        • Meirelles L.A.
        • Westcott R.A.
        Safety and clinical effectiveness of a compounded sustained-release formulation of buprenorphine for postoperative analgesia in New Zealand white rabbits.
        J Am Vet Med Assoc. 2016; 248: 795-801
        • Askar R.
        • Fredriksson E.
        • Manell E.
        • et al.
        Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits.
        BMC Vet Res. 2020; 16: 1-10
        • Andrews D.D.
        • Fajt V.R.
        • Baker K.C.
        • et al.
        A Comparison of Buprenorphine, Sustained release Buprenorphine, and High concentration Buprenorphine in Male New Zealand White Rabbits.
        J Am Assoc Lab Anim Sci. 2020; 59: 546-556
        • Freijs E.
        Comparison of plasma levels and analgesic effect between oral transmucosal and subcutaneous administration of buprenorphine in rabbits.
        Department of Clinical Science, Swedish University of Agricultural Sciences, 2016: 1-24
        • Portnoy L.
        • Hustead D.
        Pharmacokinetics of butorphanol tartrate in rabbits.
        Am J Vet Res. 1992; 53: 541-543
        • Nomura Y.
        • Hayashi S.
        Pre- and Post-Synaptic Effects of Spiradoline and U-50488H, Selective Kappa Opioid Receptor Agonists, in Isolated Ileum.
        Scand J Gastroenterol. 1992; 27: 295-302
        • Cosola C.
        • Albrizio M.
        • Guaricci A.
        • et al.
        OPIOID AGONIST/ANTAGONIST EFFECT OF NALOXONE IN.
        J Physiol Pharmacol. 2006; 57: 439-449
        • Deflers H.
        • Gandar F.
        • Bolen G.
        • et al.
        Influence of a single dose of buprenorphine on rabbit (Oryctolagus cuniculus) gastrointestinal motility.
        Vet Anaesth analgesia. 2018; 45: 510-519
        • Martin-Flores M.
        • Singh B.
        • Walsh C.A.
        • et al.
        Effects of buprenorphine, methylnaltrexone, and their combination on gastrointestinal transit in healthy New Zealand white rabbits.
        J Am Assoc Lab Anim Sci. 2017; 56: 155-159
        • Feldman E.R.
        • Singh B.
        • Mishkin N.G.
        • et al.
        Effects of Cisapride, Buprenorphine, and Their Combination on Gastrointestinal Transit in New Zealand White Rabbits.
        J Am Assoc Lab Anim Sci. 2021; 60
        • Deflers H.
        • Gandar F.
        • Bolen G.
        • et al.
        Effects of a Single Opioid Dose on Gastrointestinal Motility in Rabbits (Oryctolagus cuniculus): Comparisons among Morphine, Butorphanol, and Tramadol.
        Vet Sci. 2022; 9: 28
        • P D.
        • Di Girolamo N R.M.
        Effects of injectable analgesics on selected gastrointestinal physiologic parameters in rabbits.
        Proc ExoticsCon. 2021; : 342-343
        • Soares J.H.N.
        • Brosnan R.J.
        • Smith A.
        • et al.
        Rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine.
        Respir Physiol Neurobiol. 2014; 202: 50-52
        • Henke J.
        • Astner S.
        • Brill T.
        • et al.
        Comparative study of three intramuscular anaesthetic combinations (medetomidine/ketamine, medetomidine/fentanyl/midazolam and xylazine/ketamine) in rabbits.
        Vet Anaesth Analg. 2005; 32: 261-270
        • Shafford H.L.
        • Schadt J.C.
        Respiratory and cardiovascular effects of buprenorphine in conscious rabbits.
        Vet Anaesth Analg. 2008; 35: 326-332
        • Schroeder C.A.
        • Smith L.J.
        Respiratory rates and arterial blood gas tensions in healthy rabbits given buprenorphine, butorphanol, midazolam, or their combinations.
        J Am Assoc Lab Anim Sci. 2011; 50: 205-211
        • May C.N.
        • Ham I.W.
        • Heslop K.E.
        • et al.
        Intravenous morphine causes hypertension, hyperglycaemia and increases sympatho-adrenal outflow in conscious rabbits.
        Clin Sci. 1988; 75: 71-77
        • Raffa R.B.
        • Friderichs E.
        • Reimann W.
        • et al.
        Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an'atypical'opioid analgesic.
        J Pharmacol Exp Ther. 1992; 260: 275-285
        • Duvall A.
        Tramadol.
        J Exot Pet Med. 2017; 26: 74-77
        • Souza M.J.
        • Greenacre C.B.
        • Cox S.K.
        Pharmacokinetics of orally administered tramadol in domestic rabbits (Oryctolagus cuniculus).
        Am J Vet Res. 2008; 69: 979-982
        • Oguntoye C.O.
        • Oyewande O.A.
        • Afolabi O.O.
        Evaluation of Tramadol-Midazolam-Ketamine Anaesthesia in Rabbits.
        Niger J Physiol Sci. 2018; 33: 145-149
        • Udegbunam R.I.
        • Onuba A.C.
        • Okorie-Kanu C.
        • et al.
        Effects of two doses of tramadol on pain and some biochemical parameters in rabbits post-gastrotomy.
        Comp Clin Path. 2015; 24: 783-790
        • Egger C.M.
        • Souza M.J.
        • Greenacre C.B.
        • et al.
        Effect of intravenous administration of tramadol hydrochloride on the minimum alveolar concentration of isoflurane in rabbits.
        Am J Vet Res. 2009; 70: 945-949
        • AL-Fathee M.Y.
        • Taqa G.A.
        • AL- Jameel M.Y.
        The Effect of Tramadol on the Peristaltic Movement Small Intestine in Rabbit.
        Rafidain J Sci. 2011; 22: 1-10
        • Ali O.K.
        • Ahmed A.
        • Mawlood A.
        Effects of tramadol on histopathological and biochemical parameters in male rabbits.
        Am J Biol Life Sci. 2015; 3: 85-90
        • Papich M.G.
        • Messenger K.
        Non-steroidal anti-inflammatory drugs.
        Veterinary Anesthesia and Analgesia, 2015: 227-243
        • Audeval-Gerard C.
        • Nivet C.
        • El Amrani A.-I.
        • et al.
        Pharmacokinetics of ketoprofen in rabbit after a single topical application.
        Eur J Drug Metab Pharmacokinet. 2000; 25: 227-230
        • Fredholm D.V.
        • Carpenter J.W.
        • KuKanich B.
        • et al.
        Pharmacokinetics of meloxicam in rabbits after oral administration of single and multiple doses.
        Am J Vet Res. 2013; 74: 636-641
        • Delk K.W.
        • Carpenter J.W.
        • KuKanich B.
        • et al.
        Pharmacokinetics of meloxicam administered orally to rabbits (Oryctolagus cuniculus) for 29 days.
        Am J Vet Res. 2014; 75: 195-199
        • Turner P.V.
        • Chen C.H.
        • Taylor M.W.
        Pharmacokinetics of meloxicam in rabbits after single and repeat oral dosing.
        Comp Med. 2006; 56: 63-67
        • Carpenter J.W.
        • Pollock C.G.
        • Koch D.E.
        • et al.
        Single and multiple-dose pharmacokinetics of meloxicam after oral administration to the rabbit (Oryctolagus cuniculus).
        J Zoo Wildl Med. 2009; 40: 601-606
        • Leach M.C.
        • Allweiler S.
        • Richardson C.
        • et al.
        Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits.
        Res Vet Sci. 2009; 87: 336-347
        • Parra-Coca A.
        • Boix-Montañés A.
        • Calpena-Campmany A.C.
        • et al.
        In vivo pharmacokinetic evaluation of carprofen delivery from intra-articular nanoparticles in rabbits: A population modelling approach.
        Res Vet Sci. 2021; 137: 235-242
        • Hawkins M.
        • Taylor I.
        • Craigmill A.
        • et al.
        Enantioselective pharmacokinetics of racemic carprofen in New Zealand white rabbits.
        J Vet Pharmacol Ther. 2008; 31: 423-430
        • Hedenqvist P.
        • Trbakovic A.
        • Thor A.
        • et al.
        Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting.
        Res Vet Sci. 2016; 107: 123-131
        • Ahmad A.
        • Nawaz R.S.
        • Qureshi T.A.
        • et al.
        Histopathological effect of Meloxicam (Preferential COX-2 inhibitor NSAID) on liver and kidney of Rabbit.
        Int J Biosiences. 2017; 11: 148-158
        • Scarabelli S.
        • Nardini G.
        Gastrointestinal vasculitis and necrosis in a rabbit under long-term meloxicam treatment.
        J Exot Pet Med. 2020; 34: 26
        • De Vito V.
        • Salvadori M.
        • Poapolathep A.
        • et al.
        Pharmacokinetic/pharmacodynamic evaluation of grapiprant in a carrageenan-induced inflammatory pain model in the rabbit.
        J Vet Pharmacol Ther. 2017; 40: 468-475
        • Verret M.
        • Lauzier F.
        • Zarychanski R.
        • et al.
        Perioperative Use of Gabapentinoids for the Management of Postoperative Acute Pain: A Systematic Review and Meta-analysis.
        Anesthesiology. 2020; 133: 265-279
        • Kozer E.
        • Levichek Z.
        • Hoshino N.
        • et al.
        The Effect of Amitriptyline, Gabapentin, and Carbamazepine on Morphine-Induced Hypercarbia in Rabbits.
        Anesth Analg. 2008; 107
        • Kale A.
        • Börcek A.Ö.
        • Emmez H.
        • et al.
        Neuroprotective effects of gabapentin on spinal cord ischemia-reperfusion injury in rabbits.
        J Neurosurg Spine. 2011; 15: 228-237
        • Pang D.S.J.
        Anesthetic and analgesic Adjunctive drugs.
        Veterinary Anesthesia and Analgesia, 2015: 244-259
        • Burton M.
        • Conway R.
        • Mishkin N.
        • et al.
        Pharmacokinetics of gabapentin after single, oral administration in domestic rabbits (Oryctolagus cuniculus).
        ICARE. 2022; : 114
        • Baumgartner C.
        • Bollerhey M.
        • Ebner J.
        • et al.
        Effects of medetomidine-midazolam-fentanyl IV bolus injections and its reversal by specific antagonists on cardiovascular function in rabbits.
        Can J Vet Res. 2010; 74: 286-298
        • Marini R.P.
        • Li X.
        • Harpster N.K.
        • et al.
        Cardiovascular pathology possibly associated with ketamine/xylazine anesthesia in Dutch belted rabbits.
        Lab Anim Sci. 1999; 49: 153-160
        • Lee H.W.
        • Machin H.
        • Adami C.
        Peri-anaesthetic mortality and nonfatal gastrointestinal complications in pet rabbits: a retrospective study on 210 cases.
        Vet Anaesth Analg. 2018; 45: 520-528
        • Berry S.H.
        Injectable Anesthetics.
        Veterinary Anesthesia and Analgesia, 2015: 277-296
        • Slingsby L.S.
        • Waterman-Pearson A.E.
        The post-operative analgesic effects of ketamine after canine ovariohysterectomy—a comparison between pre- or post-operative administration.
        Res Vet Sci. 2000; 69: 147-152
        • Gianotti G.
        • Valverde A.
        • Sinclair M.
        • et al.
        Prior determination of baseline minimum alveolar concentration (MAC) of isoflurane does not influence the effect of ketamine on MAC in rabbits.
        Can J Vet Res = Revue canadienne de recherche veterinaire. 2012; 76: 261-267
        • Lipman N.S.
        • Marini R.P.
        • Erdman S.E.
        A comparison of ketamine/xylazine and ketamine/xylazine/acepromazine anesthesia in the rabbit.
        Lab Anim Sci. 1990; 40: 395-398
        • Okano S.
        • Ikeura Y.
        • Inatomi N.
        Effects of Tachykinin NK1 Receptor Antagonists on the Viscerosensory Response Caused by Colorectal Distention in Rabbits.
        J Pharmacol Exp Ther. 2002; 300: 925-931
        • Ozawa S.M.
        • Hawkins M.G.
        • Drazenovich T.L.
        • et al.
        Pharmacokinetics of maropitant citrate in New Zealand White rabbits (Oryctolagus cuniculus).
        Am J Vet Res. 2019; 80: 963-968
        • Boscan P.
        • Monnet E.
        • Mama K.
        • et al.
        Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs.
        Am J Vet Res. 2011; 72: 1576-1579
        • Sadar M.J.
        • McGee W.K.
        • Au G.G.
        • et al.
        Pilot pharmacokinetics of a higher dose of subcutaneous maropitant administration in healthy domestic rabbits (Oryctolagus cuniculus).
        J Exot Pet Med. 2022; 41: 1-2
        • Rooney T.
        • Carpenter J.W.
        • KuKanich B.
        • et al.
        Pharmacokinetics of cannabidiol administered orally in the Rabbit (Oryctolagus cuniculus).
        ExoticsCon. 2021; : 199
        • Valverde A.
        • Doherty T.J.
        • Hernández J.
        • et al.
        Effect of lidocaine on the minimum alveolar concentration of isoflurane in dogs.
        Vet Anaesth Analg. 2004; 31: 264-271
        • Schnellbacher R.W.
        • Carpenter J.W.
        • Mason D.E.
        • et al.
        Effects of lidocaine administration via continuous rate infusion on the minimum alveolar concentration of isoflurane in New Zealand White rabbits (Oryctolagus cuniculus).
        Am J Vet Res. 2013; 74: 1377-1384
        • van der Wal S.E.I.
        • van den Heuvel S.A.S.
        • Radema S.A.
        • et al.
        The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain.
        Eur J Pain. 2016; 20: 655-674
        • Antończyk A.
        • Liszka B.
        • Skrzypczak P.
        • et al.
        Comparison of analgesia provided by lidocaine or morphine delivered epidurally in rabbits undergoing hindlimb orthopedic surgery.
        Pol J Vet Sci. 2019; 22: 31-35
        • Barter L.S.
        Rabbit analgesia.
        Vet Clin Exot Anim Pract. 2011; 14: 93-104
        • Bernards C.M.
        • Artru A.A.
        Effect of intracerebroventricular picrotoxin and muscimol on intravenous bupivacaine toxicity. Evidence supporting central nervous system involvement in bupivacaine cardiovascular toxicity.
        Anesthesiology. 1993; 78: 902-910
        • Dollo G.
        • Malinovsky J.-M.
        • Péron A.
        • et al.
        Prolongation of epidural bupivacaine effects with hyaluronic acid in rabbits.
        Int J Pharm. 2004; 272: 109-119
        • Mahajan A.
        • Derian A.
        Local anesthetic toxicity.
        StatPearls Publishing, Treasure Island (FL)2021
        • Campoy L.
        • Read M.R.
        Small animal regional anesthesia and analgesia.
        John Wiley & Sons, 2013
        • Auroy Y.
        • Narchi P.
        • Messiah A.
        • et al.
        Serious complications related to regional anesthesia: results of a prospective survey in France.
        J Am Soc Anesthesiologists. 1997; 87: 479-486
        • d’Ovidio D.
        • Adami C.
        Neuropraxia after infraorbital nerve block in a pet rabbit (Oryctolagus cuniculus).
        Vet Anaesth Analg. 2021; 48: 817-819
        • d’Ovidio D.
        • Adami C.
        Locoregional Anesthesia in Exotic Pets.
        Vet Clin North Am Exot Anim Pract. 2019; 22: 301-314
        • Böhmer E.
        Dentistry in rabbits and rodents.
        1st edition. Wiley Blackwell, Chichester United Kingdom2015
        • Lichtenberger M.
        • Ko J.
        Anesthesia and analgesia for small mammals and birds.
        Vet Clin North Am Exot Anim Pract. 2007; 10: 293-315
        • Woodward T.M.
        Pain management and regional anesthesia for the dental patient.
        Top Companion Anim Med. 2008; 23: 106-114
        • Peña T.
        • Campoy L.
        • de Matos R.
        Investigation of a maxillary nerve block technique in healthy New Zealand White rabbits (Oryctolagus cuniculus).
        Am J Vet Res. 2020; 81: 843-848
        • Otero P.E.
        • Portela D.A.
        Manual of small animal regional anesthesia: Illustrated anatomy for nerve stimulation and ultrasound-guided nerve blocks.
        5M Publishing, 2019
        • Yong-Di L.
        • Zheng-Long T.
        • Jian-Qin T.
        • et al.
        Anatomy of the Inferior Alveolar Nerve in Rabbits and its Block Anesthesia.
        Int J Oral Dent Health. 2018; 4051
        • Lennox A.M.
        Clinical technique: small exotic companion mammal dentistry—anesthetic considerations.
        J Exot Pet Med. 2008; 17: 102-106
        • de Miguel Garcia C.
        • Radkey D.I.
        • Hetzel S.
        • et al.
        Injection techniques for auricular nerve blocks in the rabbit cadaver.
        Vet Anaesth Analg. 2020; 47: 274-279
        • Najman I.E.
        • Ferreira J.Z.
        • Abimussi C.J.
        • et al.
        Ultrasound-assisted periconal ocular blockade in rabbits.
        Vet Anaesth Analg. 2015; 42: 433-441
        • Hazra S.
        • Palui H.
        • Biswas B.
        • et al.
        Anesthesia for intraocular surgery in rabbits.
        Scand J Lab Anim Sci. 2011; 38: 81-87
        • de Miguel Garcia C.
        • Doss G.
        • Travis M.L.
        • et al.
        Efficacy of greater auricular and auriculotemporal nerve blocks performed in rabbits.
        Vet Anaesth Analg. 2020; 47: 567-573
        • Hawkins M.
        • Pascoe P.
        Anesthesia, Analgesia and Sedation of Small Mammals.
        in: Quezenberry K. Christoph M. Orcutt C. Ferrets, rabbits and Rodents: clinical medicine and surgery. Saunders, Philadelphia2020
        • Osofsky A.
        • LeCouteur R.A.
        • Vernau K.M.
        Functional neuroanatomy of the domestic rabbit (Oryctolagus cuniculus).
        Vet Clin North Am Exot Anim Pract. 2007; 10: 713-730
        • Fonseca C.
        • Server A.
        • Esteves M.
        • et al.
        An ultrasound-guided technique for axillary brachial plexus nerve block in rabbits.
        Lab Animal. 2015; 44: 179-184
        • Greenaway J.
        • Partlow G.
        • Gonsholt N.L.
        • et al.
        Anatomy of the lumbosacral spinal cord in rabbits.
        J Am Anim Hosp Assoc. 2001; 37: 27-34
        • d’Ovidio D.
        • Rota S.
        • Noviello E.
        • et al.
        Nerve stimulator–guided sciatic-femoral block in pet rabbits (Oryctolagus cuniculus) undergoing hind limb surgery: a case series.
        J Exot pet Med. 2014; 23: 91-95
        • Portela D.A.
        • Otero P.E.
        • Briganti A.
        • et al.
        Femoral nerve block: a novel psoas compartment lateral pre-iliac approach in dogs.
        Vet Anaesth Analg. 2013; 40: 194-204
        • Iseri T.
        • Nishimura R.
        • Nagahama S.
        • et al.
        Epidural spread of iohexol following the use of air or saline in the ‘loss of resistance’test.
        Vet Anaesth Analg. 2010; 37: 526-530
        • Otero P.E.
        • Portela D.A.
        • Brinkyer J.A.
        • et al.
        Use of electrical stimulation to monitor lumbosacral epidural and intrathecal needle placement in rabbits.
        Am J Vet Res. 2012; 73: 1137-1141
        • Doherty M.M.
        • Hughes P.J.
        • Korszniak N.V.
        • et al.
        Prolongation of lidocaine-induced epidural anesthesia by medium molecular weight hyaluronic acid formulations: pharmacodynamic and pharmacokinetic studies in the rabbit.
        Anesth Analg. 1995; 80: 740-746
        • Gusak V.
        • Turkovic V.
        • Nesek-Adam V.
        • et al.
        Lidocaine serum concentration after epidural administration in combination with morphine and fentanyl in rabbit–A preliminary study.
        Res Vet Sci. 2013; 94: 651-655
        • Novello L.
        • Corletto F.
        • Rabozzi R.
        • et al.
        Sparing effect of a low dose of intrathecal morphine on fentanyl requirements during spinal surgery: a preliminary clinical investigation in dogs.
        Vet Surg. 2008; 37: 153-160
        • Hedenqvist P.
        • Orr H.E.
        • Roughan J.V.
        • et al.
        Anaesthesia with ketamine/medetomidine in the rabbit: influence of route of administration and the effect of combination with butorphanol.
        Vet Anaesth Analg. 2002; 29: 14-19
        • Fisher P.
        • Graham J.
        Rabbits. Exotic animal formulary.
        Elsevier, St. Louis, MO2018: 494-531